Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …
Accelerated MR spectroscopic imaging—a review of current and emerging techniques
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …
Imaging Metabolism with Hyperpolarized 13C-Labeled Cell Substrates
KM Brindle - Journal of the American Chemical Society, 2015 - ACS Publications
Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …
Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients
MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …
[HTML][HTML] Lactate topography of the human brain using hyperpolarized 13C-MRI
CY Lee, H Soliman, BJ Geraghty, AP Chen… - Neuroimage, 2020 - Elsevier
Lactate is now recognized as an important intermediate in brain metabolism, but its role is
still under investigation. In this work we mapped the distribution of lactate and bicarbonate …
still under investigation. In this work we mapped the distribution of lactate and bicarbonate …
Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre‐
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …
Molecular sensors for NMR-based detection
Reliable and precise methods capable of unambiguously identifying target analytes in real-
world samples are indispensable in various fields, ranging from biological studies and …
world samples are indispensable in various fields, ranging from biological studies and …
Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart
Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13C …
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13C …
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
KR Keshari, J Kurhanewicz, R Bok… - Proceedings of the …, 2011 - National Acad Sciences
Reduction and oxidation (redox) chemistry is involved in both normal and abnormal cellular
function, in processes as diverse as circadian rhythms and neurotransmission. Intracellular …
function, in processes as diverse as circadian rhythms and neurotransmission. Intracellular …