Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P),
produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic …

Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …

Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin
resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels …

Aims/hypothesis Time-restricted eating (TRE) is suggested to improve metabolic health by
limiting food intake to a defined time window, thereby prolonging the overnight fast. This …

Per-and polyfluoroalkyl substances (PFASs) are ubiquitous environmental pollutants,
causing environmental threats and public health concerns, but information regarding PFAS …

Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role in liver
fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to …