As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

Developmental biology has contributed greatly to evolutionary biology in the past century.
With the discovery that vertebrates share Hox genes with Drosophila in 1984, it became …

Abstract Xenbase (https://www. xenbase. org/), the Xenopus model organism
knowledgebase, is a web-accessible resource that integrates the diverse genomic and …

Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …

Summary Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in
cardiovascular disease, metabolic disorder, and cancer. Outside of its role in lipid …

During vertebrate neurulation, the embryonic ectoderm is patterned into lineage progenitors
for neural plate, neural crest, placodes and epidermis. Here, we use Xenopus laevis …

A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate
axial embryonic patterning. Here we identify the tumor suppressor Protein tyrosine …

The earliest event in Xenopus development is the dorsal accumulation of nuclear β-catenin
under the influence of cytoplasmic determinants displaced by fertilization. In this study, a …

The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem
cells residing at the crypt bottom. Paneth cells form a major element of the niche …

The Xenopus laevis embryo has been subjected to almost saturating screens for molecules
specifically expressed in dorsal Spemann organizer tissue. In this study, we performed high …