[HTML][HTML] Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments
Clinical implementation of new prediction models requires evaluation of their utility in a
broad range of intended use populations. Here we develop and validate ancestry-specific …
broad range of intended use populations. Here we develop and validate ancestry-specific …
[HTML][HTML] Pharmacogenetics of lethal opioid overdose: review of current evidence and preliminary results from a pilot study
L Magarbeh, I Gorbovskaya, R Wells, R Jhirad… - Journal of personalized …, 2023 - mdpi.com
There has been a worldwide substantial increase in accidental opioid-overdose deaths. The
aim of this review, along with preliminary results from our pilot study, is to highlight the use of …
aim of this review, along with preliminary results from our pilot study, is to highlight the use of …
[HTML][HTML] Single nucleus transcriptomics reveals pervasive glial activation in opioid overdose cases
J Wei, TY Lambert, A Valada, N Patel, K Walker… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Dynamic interactions of neurons and glia in the ventral midbrain (VM) mediate reward and
addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 …
addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 …
Indirect effects of emotion regulation in the relationship between pain and cannabis use in adults 18-64 years
Introduction Individuals with chronic pain often receive prescription opioid medication, and
they may use cannabis to treat pain as well, although the risks of cannabis-opioid co-use are …
they may use cannabis to treat pain as well, although the risks of cannabis-opioid co-use are …