The role of hippo/YAP signaling in alveolar repair and pulmonary fibrosis

JJ Gokey, SD Patel, JA Kropski - Frontiers in Medicine, 2021 - frontiersin.org
Pulmonary fibrosis is characterized by loss of normal alveoli, accumulation of pathologic
activated fibroblasts, and exuberant extracellular matrix deposition that over time can lead to …

New insights into the pathogenesis of Hermansky–Pudlak syndrome

W Li, CJ Hao, ZH Hao, J Ma, QC Wang… - Pigment Cell & …, 2022 - Wiley Online Library
Hermansky–Pudlak syndrome (HPS) is characterized by defects of multiple tissue‐specific
lysosome‐related organelles (LROs), typically manifesting with oculocutaneous albinism or …

UniTmp: unified resources for transmembrane proteins

L Dobson, C Gerdán, S Tusnády… - Nucleic Acids …, 2024 - academic.oup.com
Abstract The UNIfied database of TransMembrane Proteins (UniTmp) is a comprehensive
and freely accessible resource of transmembrane protein structural information at different …

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

AC Norris, EM Yazlovitskaya, L Zhu, BS Rose… - Scientific Reports, 2024 - nature.com
Genetic association studies have linked ATP10A and closely related type IV P-type ATPases
(P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis …

Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1

H Xu, JA Oses-Prieto, M Khvotchev, S Jain… - Nature …, 2023 - nature.com
Neural systems encode information in the frequency of action potentials, which is then
decoded by synaptic transmission. However, the rapid, synchronous release of …

A role of phosphatidylserine in the function of recycling endosomes

J Hasegawa, Y Uchida, K Mukai, S Lee… - Frontiers in Cell and …, 2021 - frontiersin.org
Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the
extracellular space by endocytosis. The removal of PM by endocytosis is constantly …

Flipping the script: Advances in understanding how and why P4-ATPases flip lipid across membranes

AC Norris, AJ Mansueto, M Jimenez… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Type IV P-type ATPases (P4-ATPases) are a family of transmembrane enzymes that
translocate lipid substrates from the outer to the inner leaflet of biological membranes and …

Alveolar Organoids in Lung Disease Modeling

E Purev, K Bahmed, B Kosmider - Biomolecules, 2024 - mdpi.com
Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …

Channels and transporters of the pulmonary lamellar body in health and disease

P Dietl, M Frick - Cells, 2021 - mdpi.com
The lamellar body (LB) of the alveolar type II (ATII) cell is a lysosome-related organelle
(LRO) that contains surfactant, a complex mix of mainly lipids and specific surfactant …

PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation

C Inoue, K Mukai, T Matsudaira, J Nakayama… - Scientific Reports, 2023 - nature.com
Yes-associated protein (YAP) is a transcriptional coactivator that is essential for the
malignancy of various cancers. We have previously shown that YAP activity is positively …