Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …

Fanconi anaemia (FA) is a hereditary disease featuring hypersensitivity to DNA cross-linker-
induced chromosomal instability in association with developmental abnormalities, bone …

To clarify RAD51 interactions controlling homologous recombination, we report here the
crystal structure of the full‐length RAD51 homolog from Pyrococcus furiosus. The structure …

BRCA2 has an essential function in DNA repair by homologous recombination, interacting
with RAD51 via short motifs in the middle and at the C terminus of BRCA2. Here, we report …

The Rad51 recombinase polymerizes on ssDNA to yield a right-handed nucleoprotein
filament, called the presynaptic filament, that can search for homology in duplex DNA and …

The central catalyst in eukaryotic ATP-dependent homologous recombination consists of
RAD51 proteins, polymerized around single-stranded DNA. This nucleoprotein filament …

Homologous recombination is a central pathway to maintain genomic stability and is
involved in the repair of DNA damage and replication fork support, as well as accurate …

Homologous recombination (HR) is involved in repairing DNA double-strand breaks (DSB),
the most harmful for the cell. Regulating HR is essential for maintaining genomic stability. In …

RAD51 and other members of the RecA family of strand exchange proteins assemble on
ssDNA to form presynaptic filaments, which carry out the central steps of homologous …