The proteasome is an essential component of the ATP-dependent proteolytic pathway in
eukaryotic cells and is responsible for the degradation of most cellular proteins. The 20S …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

HIF-1α is a normally labile proangiogenic transcription factor that is stabilized and activated
in hypoxia. Although the von Hippel Lindau (VHL) gene product, the ubiquitin ligase …

Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and
ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are …

BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several
oncogenic protein kinases (eg, p185erbB2, p60v-src, and Raf-1) and is required for the …

▪ Abstract The modification of proteins by chains of ubiquitin has long been known to
mediate targeting of cytosolic and nuclear proteins for degradation by proteasomes. In this …

The twenty-first century is beginning with a sharp turn in the field of cancer therapy.
Molecular targeted therapies against specific oncogenic events are now possible. The BCR …

Cyclin D expression is regulated by growth factors and is necessary for the induction of
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine …

Currently available therapies for adult onset neurodegenerative diseases provide
symptomatic relief but do not modify disease progression. Here we explore a new …