Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS …

The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

Neuropathic pain is often caused by injury and diseases that affect the somatosensory
system. Although pain development has been well studied, pain recovery mechanisms …

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

The σ2 receptor has attracted intense interest in cancer imaging, psychiatric disease,
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …

Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …

Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and
patients typically experience fatigue and emotional distress. The etiology and …

INTRODUCTION Empathy, the adoption of another's sensory and emotional state, plays a
critical role in social interactions. Although, historically, empathy was often considered to be …