A main bottleneck in proteomics is the downstream biological analysis of highly multivariate quantitative protein abundance data generated using mass-spectrometry-based analysis …
Y Zhou, B Zhou, L Pache, M Chang… - Nature …, 2019 - nature.com
A critical component in the interpretation of systems-level studies is the inference of enriched biological pathways and protein complexes contained within OMICs datasets. Successful …
Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize …
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basis of …
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways from gene …
Our increasing understanding of cancer biology has led to the development of molecularly targeted anticancer drugs. The full potential of these agents has not, however, been …
Functional enrichment analysis is a key step in interpreting gene lists discovered in diverse high-throughput experiments. g: Profiler studies flat and ranked gene lists and finds …