Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Hepatitis delta virus (HDV) is a defective virus and a satellite of the hepatitis B virus (HBV).
Its RNA genome is unique among animal viruses, but it shares common features with some …

The directed evolution of biomolecules to improve or change their activity is central to many
engineering and synthetic biology efforts. However, selecting improved variants from gene …

An expanding number of metabolite-binding riboswitch classes are being discovered in the
noncoding portions of bacterial genomes. Findings over the last decade indicate that …

Ribozymes are noncoding RNAs that promote chemical transformations with rate
enhancements approaching those of protein enzymes. Although ribozymes are likely to …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …

Hepatitis D virus (HDV) doesn't encode envelope proteins for packaging of its
ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from …

Important biological information is encoded in the topology of biological networks.
Comparative analyses of biological networks are proving to be valuable, as they can lead to …

Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus
that it emerged before DNA and proteins, which eventually assumed these roles and …