The exploration of brain epigenomes, which consist of various types of DNA methylation and
covalent histone modifications, is providing new and unprecedented insights into the …

In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

Copy number variations have been frequently associated with developmental delay,
intellectual disability and autism spectrum disorders. MECP2 duplication syndrome is one of …

The cellular mechanism (s) underlying autism spectrum disorders (ASDs) are not fully
understood although it has been shown that various genetic and environmental factors …

Inhibitory neurons are critical for proper brain function, and their dysfunction is implicated in
several disorders, including autism, schizophrenia, and Rett syndrome. These neurons are …

Abstract Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator of gene
expression that is an important epigenetic factor in the maintenance and development of the …

Duplication of methyl-CpG-binding protein 2 (MECP2) gene causes MECP2 duplication
syndrome (MDS). To normalize the duplicated MECP2 in MDS, we developed a high-fidelity …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
symptoms related to altered social interactions/communication and restricted and repetitive …

During hippocampal development, the Cornus Ammonis (CA) and the dentate gyrus (DG)
undergo waves of neurogenesis and neuronal migration and maturation independently. This …

Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett
syndrome, a severe childhood neurological disorder. MeCP2 is a well-established …