With evidence from a large number of animal models and clinical trials, it is now beyond
debate that liver fibrosis and even cirrhosis are potentially reversible if the underlying cause …

Overweight and obese not only increase the risk of cardiovascular disease and type-2
diabetes mellitus, but are also now known risk factors for a variety of cancers. Weight control …

Liver cirrhosis involves chronic wound healing and fibrotic processes. Mesenchymal stromal
cells (MSCs) are multipotent adult progenitor cells that are used as vehicles of therapeutic …

Fibrates, such as ciprofibrate, fenofibrate, and clofibrate, are peroxisome proliferator-
activated receptor-α (PPARα) agonists that have been in clinical use for many decades for …

Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF‐1)
are common features in human liver fibrosis and cirrhosis. Signal transducer and activator of …

Androgenetic alopecia (AGA) affects more than half of the adult population worldwide and is
primarily caused by the binding of dihydrotestosterone (DHT) to androgen receptors (AR) …

High levels of insulin‐like growth factor‐1 (IGF‐1) have been associated with a significant
increase in colon cancer risk. Additionally, IGF‐1 inhibits apoptosis and stimulates …

Increase in the expression of leukocyte antigen-related (LAR) protein causes insulin
resistance, an important contributor to atherosclerosis. However, the function of LAR in …

Besides its involvement in clot lysis, the plasminogen activator (PA) system elicits various
cellular responses involved in cell migration, adhesion, and proliferation and plays a key …

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed. To
evaluate, whether IGF-II affects different stages of tumorigenesis, we induced neoplastic …