Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …

The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other
neurodevelopment defects remain poorly understood. Here, we describe the derivation and …

Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical
significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes …

Nucleoside precursors and nucleoside analogs occupy an important place in the treatment
of viral respiratory pathologies, especially during the current COVID-19 pandemic. From this …

Zika virus (ZIKV) infection during pregnancy leads to devastating fetal outcomes, including
intrauterine growth restriction and microcephaly. Greater understanding of mechanisms …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

Arthropod-borne flaviviruses are human pathogens of global medical importance, against
which no effective small molecule-based antiviral therapy has currently been reported …

Zika virus is an emerging flavivirus that causes the neurodevelopmental congenital Zika
syndrome and that has been linked to the neuroinflammatory Guillain–Barré syndrome. The …

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected
clinical manifestations. Antiviral development is of high priority in response to the ZIKV …