The role of DEAD-box ATPases in gene expression and the regulation of RNA–protein condensates
DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
D Overwijn, M Hondele - Trends in Biochemical Sciences, 2023 - cell.com
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that
determine their driving forces for phase separation. Here we uncover the physicochemical …
determine their driving forces for phase separation. Here we uncover the physicochemical …
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
LA Gruijs da Silva, F Simonetti, S Hutten… - The EMBO …, 2022 - embopress.org
Post‐translational modifications (PTMs) have emerged as key modulators of protein phase
separation and have been linked to protein aggregation in neurodegenerative disorders …
separation and have been linked to protein aggregation in neurodegenerative disorders …
Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation
Liquid-liquid phase separation or LLPS of proteins is a field of mounting importance and the
value of quantitative kinetic and thermodynamic characterization of LLPS is increasingly …
value of quantitative kinetic and thermodynamic characterization of LLPS is increasingly …
Biomolecular condensates: Sequence determinants of phase separation, microstructural organization, enzymatic activity, and material properties
BS Schuster, RM Regy, EM Dolan… - The journal of …, 2021 - ACS Publications
This perspective article highlights recent progress and emerging challenges in
understanding the formation and function of membraneless organelles (MLOs). A long-term …
understanding the formation and function of membraneless organelles (MLOs). A long-term …
Intrinsically disordered regions that drive phase separation form a robustly distinct protein class
AI Ibrahim, N Khaodeuanepheng, D Amarasekara… - Biophysical …, 2023 - cell.com
Liquid-liquid phase separation (LLPS) of proteins is thought to be a primary driving force for
the formation of membraneless organelles, which control a wide range of biological …
the formation of membraneless organelles, which control a wide range of biological …
Structural and functional organization of germ plasm condensates
Reproductive success of metazoans relies on germ cells. These cells develop early during
embryogenesis, divide and undergo meiosis in the adult to make sperm and oocytes. Unlike …
embryogenesis, divide and undergo meiosis in the adult to make sperm and oocytes. Unlike …
[PDF][PDF] Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
LAG Da Silva, F Simonetti, S Hutten… - Embo …, 2022 - openscience.ub.uni-mainz.de
Post-translational modifications (PTMs) have emerged as key modulators of protein phase
separation and have been linked to protein aggregation in neurodegenerative disorders …
separation and have been linked to protein aggregation in neurodegenerative disorders …
Surface tension measurement and calculation of model biomolecular condensates
The surface tension of liquid-like protein-rich biomolecular condensates is an emerging
physical principle governing the mesoscopic interior organisation of biological cells. In this …
physical principle governing the mesoscopic interior organisation of biological cells. In this …