Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

CW Schultz, R Preet, T Dhir, DA Dixon… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

The RNA-binding protein HuR in human cancer: a friend or foe?

X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

Mitoxantrone, more than just another topoisomerase II poison

BJ Evison, BE Sleebs, KG Watson… - Medicinal research …, 2016 - Wiley Online Library
Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic
profile of the anthracyclines and is commonly applied in the treatment of breast and prostate …

Heterogeneity in mRNA translation

S Sonneveld, BMP Verhagen, ME Tanenbaum - Trends in cell biology, 2020 - cell.com
During mRNA translation, the genetic information stored in mRNA is translated into a protein
sequence. It is imperative that the genetic information is translated with high precision …

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

X Wu, G Gardashova, L Lan, S Han, C Zhong… - Communications …, 2020 - nature.com
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction

X Wu, L Lan, DM Wilson, RT Marquez… - ACS chemical …, 2015 - ACS Publications
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …

Perfluoroalkyl acid binding with peroxisome proliferator-activated receptors α, γ, and δ, and fatty acid binding proteins by equilibrium dialysis with a comparison of …

M Khazaee, E Christie, W Cheng, M Michalsen, J Field… - Toxics, 2021 - mdpi.com
The biological impacts of per-and polyfluorinated alkyl substances (PFAS) are linked to their
protein interactions. Existing research has largely focused on serum albumin and liver fatty …

Fluorescence sensing of circulating diagnostic biomarkers using molecular probes and nanoparticles

O Tagit, N Hildebrandt - ACS sensors, 2017 - ACS Publications
The interplay of photonics, nanotechnology, and biochemistry has significantly improved the
identification and characterization of multiple types of biomarkers by optical biosensors …