S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of …
X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis elements present in mRNAs whose stability and translation are subject to regulation. The …
The control of eukaryotic gene expression occurs at multiple levels, from transcription to messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
BJ Evison, BE Sleebs, KG Watson… - Medicinal research …, 2016 - Wiley Online Library
Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic profile of the anthracyclines and is commonly applied in the treatment of breast and prostate …
During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision …
X Wu, G Gardashova, L Lan, S Han, C Zhong… - Communications …, 2020 - nature.com
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
X Wu, L Lan, DM Wilson, RT Marquez… - ACS chemical …, 2015 - ACS Publications
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′- untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …
The biological impacts of per-and polyfluorinated alkyl substances (PFAS) are linked to their protein interactions. Existing research has largely focused on serum albumin and liver fatty …
The interplay of photonics, nanotechnology, and biochemistry has significantly improved the identification and characterization of multiple types of biomarkers by optical biosensors …