Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

Background Major depressive disorder (MDD) is characterized by elevated activity of
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …

Introduction High-inflammation subgroups of patients with psychosis demonstrate cognitive
deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C …

Inflammation is associated with depressive symptoms and innate immune mechanisms are
likely causal in some cases of major depression. Systemic inflammation also perturbs brain …

Compelling evidence demonstrates that some individuals suffering from major depressive
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …

Background The dentate gyrus (DG) has been implicated in the pathophysiology of
depression. Many studies have revealed the cellular types, neural circuits, and …

Cognitive impairments, such as learning and memory deficits, may occur in susceptible
populations including the elderly and patients who are chronically ill or have experienced …

Abstract Major Depressive Disorder (MDD) is marked by abnormal brain function and
elevated plasma oxidative stress markers. The specific relationship between these factors in …

We have previously proposed that mothers and infants co-regulate one another's autonomic
state through an autonomic conditioning mechanism, which starts during gestation and …