Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Objective: To summarize prevalence data on the neurologic complications of sickle cell
disease (SCD) in Africa. Methods: We searched EMBASE, PubMed, and African Index …

Sickle cell anemia (SCA) carries orphan disease designation in the United States, with;
2000 affected infants born annually and fewer than 100 000 persons living with this …

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a mutation in the
sixth amino acid of the β-globin gene (HBB). It is the most common serious genetic diseases …

In sub-Saharan Africa, sickle cell anemia (SCA) remains a significant public health problem
with high mortality: an estimated 50-90% of affected children die before 5 years of age. 1 A …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Background/objective Sickle cell disease (SCD) is a monogenic disease with multiple
phenotypic expressions. Previous studies describing SCD clinical phenotypes in Nigeria …

Background Sickle cell disease (SCD) is a common autosomal recessive inherited
hemoglobin disorder in many countries. Neurological complications are among the most …

Background Cerebrovascular stroke is a common critical complication of sickle cell disease
(SCD). Angiotensinogen (AGT) M235T gene polymorphism is associated with risk of …

We conducted a systematic review for evaluating the impact of hydroxyurea and chronic
blood transfusion in children with sickle cell disease (SCD). A search was done in four …