[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways
U Seroussi, C Li, AE Sundby, TL Lee… - Seminars in Cell & …, 2022 - Elsevier
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Maternal DOT1L is dispensable for mouse development
J Liao, PE Szabó - Scientific reports, 2020 - nature.com
A battery of chromatin modifying enzymes play essential roles in remodeling the epigenome
in the zygote and cleavage stage embryos, when the maternal genome is the sole …
in the zygote and cleavage stage embryos, when the maternal genome is the sole …
A transcriptional cofactor regulatory network for the C. elegans intestine
BB Horowitz, S Nanda… - G3: Genes, Genomes …, 2023 - academic.oup.com
Chromatin modifiers and transcriptional cofactors (collectively referred to as CFs) work with
DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular …
DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular …
DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans
LI Lascarez-Lagunas, E Herruzo, A Grishok… - PLoS …, 2020 - journals.plos.org
Epigenetic modifiers are emerging as important regulators of the genome. However, how
they regulate specific processes during meiosis is not well understood. Methylation of …
they regulate specific processes during meiosis is not well understood. Methylation of …
Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions
The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by
the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 …
the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 …
Male-specific behavioral and transcriptomic changes in aging C. elegans neurons
Aging is a complex biological process with sexually dimorphic aspects. Although cognitive
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about …
[HTML][HTML] DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation
T Liontis, K Verma, A Grishok - BBA advances, 2023 - Elsevier
Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is
accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C …
accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C …
Male-specific features of C. elegans neuronal aging
Aging is a complex biological process, with sexually dimorphic aspects. For example, men
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …
and women differ in their vulnerabilities in cognitive decline, suggesting biological sex may …
[HTML][HTML] The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters
The only representative of the MYC superfamily transcription factors in C. elegans, MML-1
(Myc and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …
(Myc and Mondo-like 1), was shown to promote extended lifespan in a variety of models and …