Epithelial pyroptosis in host defense
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins
called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases …
called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases …
[HTML][HTML] Forced into shape: Mechanical forces in Drosophila development and homeostasis
Mechanical forces play a central role in shaping tissues during development and
maintaining epithelial integrity in homeostasis. In this review, we discuss the roles of …
maintaining epithelial integrity in homeostasis. In this review, we discuss the roles of …
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers
AC Fasciano, GS Dasanayake, MK Estes… - Gut …, 2021 - Taylor & Francis
Many pathogens use M cells to access the underlying Peyer's patches and spread to
systemic sites via the lymph as demonstrated by ligated loop murine intestinal models …
systemic sites via the lymph as demonstrated by ligated loop murine intestinal models …
[HTML][HTML] Desmosome-anchored intermediate filaments facilitate tension-sensitive RhoA signaling for epithelial homeostasis
Epithelia are subject to diverse forms of mechanical stress during development and post-
embryonic life. They possess multiple mechanisms to preserve tissue integrity against …
embryonic life. They possess multiple mechanisms to preserve tissue integrity against …
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity
Apical‐basal polarity is maintained by distinct protein complexes that reside in membrane
junctions, and polarity loss in monolayered epithelial cells can lead to formation of …
junctions, and polarity loss in monolayered epithelial cells can lead to formation of …
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion
R Ventrella, SK Kim, J Sheridan, A Grata… - …, 2023 - journals.biologists.com
Xenopus embryos are covered with a complex epithelium containing numerous multiciliated
cells (MCCs). During late-stage development, there is a dramatic remodeling of the …
cells (MCCs). During late-stage development, there is a dramatic remodeling of the …
Multicellular aligned bands disrupt global collective cell behavior
Mechanical stress patterns emerging from collective cell behavior have been shown to play
critical roles in morphogenesis, tissue repair, and cancer metastasis. In our previous work …
critical roles in morphogenesis, tissue repair, and cancer metastasis. In our previous work …
Pleiotropic effects of cell competition between normal and transformed cells in mammalian cancers
J Yu, Y Zhang, H Zhu - Journal of Cancer Research and Clinical Oncology, 2023 - Springer
Purpose In the course of tumor progression, cancer clones interact with host normal cells,
and these interactions make them under selection pressure all the time. Cell competition …
and these interactions make them under selection pressure all the time. Cell competition …
A single stiffened nucleus alters cell dynamics and coherence in a monolayer
Force transmission throughout a monolayer is the result of complex interactions between
cells. Monolayer adaptation to force imbalances such as singular stiffened cells provides …
cells. Monolayer adaptation to force imbalances such as singular stiffened cells provides …
A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development
We discovered that apocrine secretion by embryonic choroid plexus (ChP) epithelial cells
contributes to the cerebrospinal fluid (CSF) proteome and influences brain development in …
contributes to the cerebrospinal fluid (CSF) proteome and influences brain development in …