Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs
I Bjarnason, C Scarpignato, E Holmgren, M Olszewski… - Gastroenterology, 2018 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract,
causing widespread morbidity and mortality. Although mechanisms of damage involve the …
causing widespread morbidity and mortality. Although mechanisms of damage involve the …
NSAID–gut microbiota interactions
D Maseda, E Ricciotti - Frontiers in pharmacology, 2020 - frontiersin.org
Nonsteroidal anti-inflammatory drugs (NSAID) s relieve pain, inflammation, and fever by
inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical …
inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical …
[HTML][HTML] Interactions between NSAIDs, opioids and the gut microbiota-future perspectives in the management of inflammation and pain
The composition of intestinal microbiota is influenced by a number of factors, including
medications, which may have a substantial impact on host physiology. Nonsteroidal anti …
medications, which may have a substantial impact on host physiology. Nonsteroidal anti …
Nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and gastrointestinal injury: contrasting interactions in the stomach and small intestine
W Marlicz, I Łoniewski, DS Grimes, EM Quigley - Mayo Clinic Proceedings, 2014 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) are
among the most frequently prescribed groups of drugs worldwide. The use of NSAIDs is …
among the most frequently prescribed groups of drugs worldwide. The use of NSAIDs is …
Computational design, synthesis, and pharmacological evaluation of naproxen-guaiacol chimera for gastro-sparing anti-inflammatory response by selective COX2 …
The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its
antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore …
antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore …
Are all oral COX‐2 selective inhibitors the same? A consideration of celecoxib, etoricoxib, and diclofenac
C Walker - International journal of rheumatology, 2018 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) have been widely used for the treatment of
arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by …
arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by …
The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton …
T Yoshihara, Y Oikawa, T Kato, T Kessoku… - Gut …, 2020 - Taylor & Francis
ABSTRACT Background Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal
injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study …
injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study …
Mitochondrial potassium channels as pharmacological target for cardioprotective drugs
L Testai, S Rapposelli, A Martelli… - Medicinal Research …, 2015 - Wiley Online Library
Brief periods of ischemia are known to confer to the myocardium an increased resistance to
the injury due to a later and more prolonged ischemic episode. This phenomenon, known as …
the injury due to a later and more prolonged ischemic episode. This phenomenon, known as …
Use of Saccharomyces boulardii CNCM I‐745 as therapeutic strategy for prevention of nonsteroidal anti‐inflammatory drug‐induced intestinal injury
V D'Antongiovanni, L Antonioli… - British Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Nonsteroidal anti‐inflammatory drugs (NSAIDs) can be
associated with severe adverse digestive effects. This study examined the protective effects …
associated with severe adverse digestive effects. This study examined the protective effects …
NSAID-associated small intestinal injury: an overview from animal model development to pathogenesis, treatment, and prevention
M Zhang, F Xia, S Xia, W Zhou, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
With the wide application of non-steroidal anti-inflammatory drugs (NSAIDs), their
gastrointestinal side effects are an urgent health burden. There are currently sound …
gastrointestinal side effects are an urgent health burden. There are currently sound …