Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

RJ Reiter, R Sharma, F Simko… - Cellular and Molecular …, 2022 - Springer
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

DX Tan, RJ Reiter - Life Sciences, 2022 - Elsevier
The fear of SARS-CoV-2 infection is due to its high mortality related to seasonal flu. To date,
few medicines have been developed to significantly reduce the mortality of the severe …

BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster

S Pal, A Sahu, R Verma, C Haldar - Journal of Pineal Research, 2023 - Wiley Online Library
Ever‐increasing occurrence of plastic‐manufacturing industries leads to environmental
pollution that has been associated with declined human health and increased incidence of …

Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease

FG Saqallah, MA Abbas, HA Wahab - Phytochemistry, 2022 - Elsevier
Dengue virus (DENV) is an arbovirus widespread through tropical and subtropical areas. It
is transmitted to humans through Aedes mosquitoes. Infections with DENV can lead to a …

A mid-pandemic night's dream: Melatonin, from harbinger of anti-inflammation to mitochondrial savior in acute and long COVID-19

IG Lempesis, VE Georgakopoulou… - International …, 2024 - spandidos-publications.com
Coronavirus disease 2019 (COVID-19), a systemic illness caused by severe acute
respiratory distress syndrome 2 (SARS-CoV-2), has triggered a worldwide pandemic with …

INMI1 Zika virus NS4B antagonizes the interferon signaling by suppressing STAT1 phosphorylation

E Fanunza, N Grandi, M Quartu, F Carletti, L Ermellino… - Viruses, 2021 - mdpi.com
The evasion of the Interferon response has important implications in Zika virus (ZIKV)
disease. Mutations in ZIKV viral protein NS4B, associated with modulation of the interferon …

A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin …

V Chattree, K Singh, K Singh, A Goel… - Journal of food …, 2022 - Wiley Online Library
SARS‐CoV‐2 infection has now become the world's most significant health hazard, with the
World Health Organization declaring a pandemic on March 11, 2020. COVID‐19 enters the …

Melatonin attenuates LPS-induced ovarian toxicity via modulation of SIRT-1, PI3K/pAkt, pErk1/2 and NFĸB/COX-2 expressions

S Pal, C Haldar, R Verma - Toxicology and applied pharmacology, 2022 - Elsevier
The association between inflammation and metabolic disturbances leads to various female
pathophysiological conditions. Bacterial lipopolysaccharide (LPS), found in the outer …

A review of the potential effects of melatonin in compromised mitochondrial redox activities in elderly patients with COVID-19

WL Su, CC Wu, SFV Wu, MC Lee, MT Liao… - Frontiers in …, 2022 - frontiersin.org
Melatonin, an endogenous indoleamine, is an antioxidant and anti-inflammatory molecule
widely distributed in the body. It efficiently regulates pro-inflammatory and anti-inflammatory …

In silico homology modeling of dengue virus non-structural 4B (NS4B) protein and its molecular docking studies using triterpenoids

S Ali, U Ali, K Safi, F Naz, MI Jan, Z Iqbal, T Ali… - BMC Infectious …, 2024 - Springer
Background Dengue fever has become a significant worldwide health concern, because of
its high morbidity rate and the potential for an increase in mortality rates due to lack of …