Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of
mortality among men. The recurrent reports of false-positive results of common PCa …

Simple Summary Liquid biopsy (LB), encompassing the analysis of circulating tumor
material in the blood or urine, has emerged as a powerful tool in the management of …

Gastrointestinal (GI) cancers are one of the most common causes of cancer-related mortality.
The discovery of microRNAs (miRs) and their unique role in cancer and other diseases has …

Carbonic anhydrase (CA) is a metalloenzyme that catalyzes the interconversion between
carbon dioxide and water and dissociated ions of carbonic acid. In addition, CA performs …

Purpose This article summarizes current androgen receptor (AR)–directed therapies that
have received regulatory approval for the treatment of advanced prostate adenocarcinoma …

Objective: To review pharmacology, efficacy, safety, and considerations for use, of second-
generation androgen receptor (AR) antagonists in treatment of nonmetastatic castrate …

Proteolysis-targeting chimaeras (PROTACs) have been developed to be an emerging
technology for targeted protein degradation and attracted the favour of academic institutions …

Prostate cancer (PCa) is considered one of the most prevalent male malignancies
worldwide with a global burden estimated to increase over the next two decades. Due to …

The mutation-driven transformation of clinical anti-androgen drugs into agonists of the
human androgen receptor (AR) represents a major challenge for the treatment of prostate …

The androgen receptor (AR) has been shown to be a key determinant in the pathogenesis of
castration‐resistant prostate cancer (CRPC). The current standard of care therapies targets …