Background and aims COVID-19 is a dominant pulmonary disease, with multisystem
involvement, depending upon comorbidities. Its profile in patients with pre-existing chronic …

Patients with cirrhosis of the liver are at high risk of developing portal vein thrombosis (PVT),
which has a complex, multifactorial cause. The condition may present with a myriad of …

Abstract Background & Aim Hepatitis B reactivation related to the use of immunosuppressive
therapy remains a major cause of liver-related morbidity and mortality in hepatitis B endemic …

Background Patients with cirrhosis have profoundly altered hemodynamics and hemostatic
pathways with procoagulant and anticoagulant mechanisms, resulting in a tenuous …

Background & Aims Endothelial injury and dysfunction play a detrimental role in the
pathogenesis of infections. Endothelium-related molecules have been reported as potential …

Liver transplantation is the only curative treatment for end-stage liver disease. Unfortunately,
the scarcity of donor organs and the increasing pool of potential recipients limit access to …

Extracellular vesicles (EVs) are membrane-derived vesicles released by a variety of cell
types, including hepatocytes, hepatic stellate cells, and immune cells in normal and …

Liver failure in the context of acute (ALF) and acute on chronic liver failure (ACLF) is
associated with high mortality in the absence of a liver transplant. For decades, therapeutic …

Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely
decompensated chronic liver disease. It is characterised by high 28-day mortality, the …

BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure
(HBV-ACLF) present a complex and poor prognosis. Systemic inflammation plays an …