Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease
ED Fowler, S Zissimopoulos - Biomolecules, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds
N Silbernagel, A Körner, J Balitzki, M Jaggy, S Bertels… - Biomaterials, 2020 - Elsevier
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) represent the best
cell source for cardiac regenerative purposes but retain an immature phenotype after …
cell source for cardiac regenerative purposes but retain an immature phenotype after …
Limiting RyR2 open time prevents Alzheimer's disease-related neuronal hyperactivity and memory loss but not β-amyloid accumulation
Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …
Size matters: ryanodine receptor cluster size affects arrhythmogenic sarcoplasmic reticulum calcium release
Background Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+)
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …
CMYA5 establishes cardiac dyad architecture and positioning
Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains
formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic …
formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic …
Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Abstract Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain.
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …
Mutations in RyR2 are associated with both cardiac arrhythmias and intellectual disability …
Modeling Calcium Cycling in the Heart: Progress, Pitfalls, and Challenges
Intracellular calcium (Ca) cycling in the heart plays key roles in excitation–contraction
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca2+ sparks constitute the fundamental units of Ca2+ release in cardiomyocytes. Here we
investigate how ryanodine receptors (RyRs) collectively generate these events by …
investigate how ryanodine receptors (RyRs) collectively generate these events by …
Virally delivered CMYA5 enhances the assembly of cardiac dyads
F Lu, C Liou, Q Ma, Z Wu, B Xue, Y Xia, S Xia… - Nature Biomedical …, 2024 - nature.com
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack
nanoscale structures essential for efficient excitation–contraction coupling. Such …
nanoscale structures essential for efficient excitation–contraction coupling. Such …
[HTML][HTML] Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca2+ handling dysfunction in rats with pulmonary artery hypertension
ED Fowler, MJ Drinkhill, R Norman… - Journal of Molecular and …, 2018 - Elsevier
Right heart failure is the major cause of death in Pulmonary Artery Hypertension (PAH)
patients but is not a current, specific therapeutic target. Pre-clinical studies have shown that …
patients but is not a current, specific therapeutic target. Pre-clinical studies have shown that …