In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …

Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http//thebiogrid. org) is an open access archive of genetic and protein interactions that are …

The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …

Pyroptosis is an inflammasome-mediated programmed cell death pathway triggered in
macrophages by a variety of stimuli, including intracellular bacterial pathogens. Activation of …

Developmental transitions between single-cell yeast and multicellular filaments underpin
virulence of diverse fungal pathogens. For the leading human fungal pathogen Candida …

Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction
analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR …

The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis,
causing infections ranging from superficial to life-threatening disseminated disease. The …

INTRODUCTION Whole-genome duplication (WGD) events are pervasive in eukaryotes,
shaping the genomes of simple single-celled organisms, such as yeast, as well as those of …

Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …