Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

Available treatment methods have shown little effect on the burden associated with mental
health disorders. We review promising universal, selective, and indicated preventive mental …

Importance Individuals with mental disorders often develop comorbidity over time. Past
studies of comorbidity have often restricted analyses to a subset of disorders and few studies …

Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …

Evidence of executive dysfunction in autism spectrum disorders (ASD) across development
remains mixed and establishing its role is critical for guiding diagnosis and intervention. The …

Outcomes of psychotic disorders are associated with high personal, familiar, societal and
clinical burden. There is thus an urgent clinical and societal need for improving those …

The “at risk mental state” for psychosis approach has been a catalytic, highly productive
research paradigm over the last 25 years. In this paper we review that paradigm and …

Mental disorders frequently begin in childhood or adolescence. Psychotropic medications
have various indications for the treatment of mental disorders in this age group and are used …

Importance Social and occupational impairments contribute to the burden of psychosis and
depression. There is a need for risk stratification tools to inform personalized functional …

Recognizing that current frameworks for classification and treatment in psychiatry are
inadequate, particularly for use in young people and early intervention services …