Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

The biofunctionalization of synthetic materials has extensive utility for biomedical
applications, but approaches to bioconjugation typically show insufficient efficiency and …

Immunoengineering applies quantitative and materials-based approaches for the
investigation of the immune system and for the development of therapeutic solutions for …

Chimeric antigen receptor (CAR)-engineered T cells represent a front-line therapy for
cancers. However, the current CAR T cell manufacturing protocols do not adequately …

Activation of T cells by antigen presenting cells (APCs) initiates their proliferation, cytokine
production, and killing of infected or cancerous cells. We and others have shown that T-cell …

Yeast surface display is an appealing technique for constructing multienzyme cascades.
This technique is commonly achieved using a scaffold for the ordered arrangement of …

Ligand spatial presentation and density play important roles in signaling pathways mediated
by cell receptors and are critical parameters when designing protein-conjugated therapeutic …

Over the past two decades, enzyme catalysis has emerged as an economical and
environmentally friendly alternative to conventional catalysis with numerous applications in …

Cooperative enzyme catalysis in nature has long inspired the application of engineered
multi-enzyme assemblies for industrial biocatalysis. Despite considerable interest, efforts to …

Yeast surface display has proven to be a powerful tool for the discovery of antibodies and
other novel binding proteins and for engineering the affinity and selectivity of existing …