Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation
of membraneless compartments in cells. This realization has motivated major efforts to …

Optical contrasts in microscopy are sensitive to light polarization, whose interaction with
molecular dipoles provides an important lever for probing molecular orientation. Polarization …

For decades, biologists have relied on software to visualize and interpret imaging data. As
techniques for acquiring images increase in complexity, resulting in larger multidimensional …

Regulation of order, such as orientation and conformation, drives the function of most
molecular assemblies in living cells but remains difficult to measure accurately through …

Fluorescent molecules are like antennas: The rate at which they absorb light depends on
their orientation with respect to the incoming light wave, and the apparent intensity of their …

The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal
cells, yet its filament organization and the mechanism of contractility is not well understood …

Most essential cellular functions are performed by proteins assembled into larger
complexes. Fluorescence Polarization Microscopy (FPM) is a powerful technique that goes …

Septins are conserved filament-forming proteins that act in diverse cellular processes. They
closely associate with membranes and, in some systems, components of the cytoskeleton. It …

Desmosomes are macromolecular cell-cell junctions that provide adhesive strength in
epithelial tissue. Desmosome function is inseparably linked to structure, and it is …

Background Hepatocellular carcinoma (HCC) represents one of the most significant causes
of mortality due to cancer-related deaths. It has been previously reported that the TGF-β …