The social salience hypothesis of oxytocin

SG Shamay-Tsoory, A Abu-Akel - Biological psychiatry, 2016 - Elsevier
Oxytocin is a nonapeptide that also serves as a neuromodulator in the human central
nervous system. Over the last decade, a sizeable body of literature has examined its effects …

Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development

GF Koob, R Dantzer - Pharmacological reviews, 2021 - Elsevier
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior

KM Dumais, AH Veenema - Frontiers in neuroendocrinology, 2016 - Elsevier
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are
involved in the regulation of various social behaviors and have emerged as drug targets for …

Psychobiological mechanisms underlying the social buffering of the hypothalamic–pituitary–adrenocortical axis: A review of animal models and human studies across …

CE Hostinar, RM Sullivan, MR Gunnar - Psychological bulletin, 2014 - psycnet.apa.org
Discovering the stress-buffering effects of social relationships has been one of the major
findings in psychobiology in the last century. However, an understanding of the underlying …

Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications

M Numan, LJ Young - Hormones and behavior, 2016 - Elsevier
This article is part of a Special Issue “Parental Care”. Mother–infant bonding is a
characteristic of virtually all mammals. The maternal neural system may have provided the …

[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Biased oxytocinergic modulation of midbrain dopamine systems

L Xiao, MF Priest, J Nasenbeny, T Lu, Y Kozorovitskiy - Neuron, 2017 - cell.com
The release of dopamine (DA) regulates rewarding behavior and motor actions through
striatum-targeting efferents from ventral tegmental area (VTA) and substantia nigra pars …

Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans

R Hurlemann, A Patin, OA Onur, MX Cohen… - Journal of …, 2010 - Soc Neuroscience
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans
with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the …

Neuromodulation by oxytocin and vasopressin

R Stoop - Neuron, 2012 - cell.com
Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for
their peripheral hormonal effects. Specific receptors have also been found in the brain …

Oxytocin: the great facilitator of life

HJ Lee, AH Macbeth, JH Pagani, WS Young 3rd - Progress in neurobiology, 2009 - Elsevier
Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition.
Since 1906 when its uterine-contracting properties were described until 50 years later when …