Epigenetic mechanisms, including DNA methylation and histone post‐translational
modifications (PTMs), have been known to regulate chromatin structure and lineage‐specific …

Systemic hypertension, which eventually results in heart failure, renal failure or stroke, is a
common chronic human disorder that particularly affects elders. Although many signaling …

Phenotypic alterations in resident vascular cells contribute to the vascular remodeling
process in diseases such as pulmonary (arterial) hypertension [P (A) H]. How the molecular …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Pulmonary arterial hypertension (PAH) is a progressive vascular remodeling disease
characterized by a persistent elevation of pulmonary artery pressure, leading to right heart …

Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause early
right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves …

Pulmonary arterial hypertension (PAH) is a disease with complex pathobiology, significant
morbidity and mortality, and remains without a cure. It is characterized by vascular …

Pulmonary vascular remodeling due to excessive proliferation and resistance to apoptosis of
pulmonary artery smooth muscle cells (PASMCs) is the hallmark feature of pulmonary …

Pulmonary hypertension (PH) is characterized by a progressive increase in pulmonary
arterial pressure and pulmonary vascular resistance. In a short time, it leads to right …

The pathobiology of pulmonary arterial hypertension (PAH) is complex and incompletely
understood. Although three pathogenic pathways have been relatively well characterised, it …