Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Stroke is the second leading cause of death and the third leading cause of disability
worldwide and its burden is increasing rapidly in low-income and middle-income countries …

Executive summary Stroke is the second leading cause of death worldwide. The burden of
disability after a stroke is also large, and is increasing at a faster pace in low-income and …

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …

Protease-activated receptor 4 (PAR4)(gene F2RL3) harbors a functional dimorphism,
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …

In 2015, the United Nations set important targets to reduce premature cardiovascular
disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD …

Background and purpose Acute ischemic stroke is one of the leading causes of disability
and mortality globally, with increasing incidence in Africa, as the continent is already …

Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia.
Previous studies on the prevalence of cSVD are mostly based on single geographically …

Endothelial dysfunction is characterized by a reduction in nitric oxide generation or an
unbalanced distribution of the relaxing and contracting pressures produced by endothelial …

Background Every minute, six indigenous Africans develop new strokes. Patient-level and
system-level contributors to early stroke fatality in this region are yet to be delineated. We …