Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …

The progression of tuberculosis from a latent, subclinical infection to active disease that
culminates in the transmission of infectious bacilli is determined locally at the level of the …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

Interferon-γ is key in limiting Mycobacterium tuberculosis infection. Here we show that
vaccination triggered an accelerated interferon-γ response by CD4+ T cells in the lung …

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …

Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis
and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but …

The progression of human tuberculosis (TB) to active disease and transmission involves the
development of a caseous granuloma that cavitates and releases infectious Mycobacterium …

Tuberculosis (TB), an illness that mainly affects the respiratory system, is one of the world's
most pernicious diseases. TB currently infects one-third of the world's population and kills …