Glioma targeted therapy: insight into future of molecular approaches
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
The use of alternative strategies for enhanced nanoparticle delivery to solid tumors
M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
decade. Classically, scientists have tried to improve NM delivery by employing passive or …
Tumor angiogenesis: causes, consequences, challenges and opportunities
R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …
vary between tumor type and anatomic location, but also occur simultaneously within the …
Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
CD Arvanitis, GB Ferraro, RK Jain - Nature Reviews Cancer, 2020 - nature.com
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …
survival have been modest and, in some examples, less than those of other approved …
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
Angiogenesis as a hallmark of solid tumors-clinical perspectives
J Majidpoor, K Mortezaee - Cellular Oncology, 2021 - Springer
Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …