Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene
delivery. Despite the resources poured into the development of ever more effective …

Mannosylation of Lipid Nanoparticles (LNP) can potentially enhance uptake by Antigen
Presenting Cells, which are highly abundant in dermal tissues, to improve the potency of …

In the current phase of medical progress, practical neuro-oncology faces critical challenges.
These include the quest for and development of innovative methodological approaches, as …

We provide evidence that cationic lipids, usually considered as a safe alternative to viral
vectors as nanocarriers for gene therapy or drug intracellular delivery, do not behave as …

Prostate cancer is one of the most common cancers in men. Despite the development of a
variety of therapeutic agents to treat either metastatic hormone-sensitive prostate cancer …

In recent decades, cancer immunotherapy has demonstrated considerable clinical
advantages in cancer therapy. Particularly, the use of immunological gene therapy …

Highlights•Clinical evaluation of nanocarriers for macromolecules is discussed.•
Nanocarriers for immunotherapy and gene delivery have advanced to the clinic.•Challenges …

Cationic polymers are amongst the most utilized non-viral vectors for gene transfer owing to
their ability to condense and protect the genetic material within polyplexes and to ferry it into …

Skeletal systems provide support, movement, and protection to the human body. It can be
affected by several life suffering bone disorders such as osteoporosis, osteoarthritis, and …