S Pattanaik, C Monchaud - Therapeutic Drug Monitoring, 2025 - journals.lww.com
The concept of pharmacokinetic (PK) boosting of calcineurin inhibitors (CNI) emerged after the FDA approval of cyclosporine-A. Several studies followed, and the proof of concept was …
Summary Aims and Objectives:(i) To describe an example of the development work required for building a 'pediatric physiologically based pharmacokinetic'(P‐PBPK) model (Simcyp …
Nephrotic syndrome is a common childhood glomerular disease that is associated with massive proteinuria and edema. Children with nephrotic syndrome are at risk of chronic …
S Banerjee, M Bonilla-Felix - Pediatric Nephrology, 2024 - Springer
The management of focal segmental glomerulosclerosis (FSGS) is challenging, and a definitive long-term cure remains elusive. It is associated with poor outcomes due to …
Introduction: Cyclosporine A is used in the treatment of idiopathic nephrotic syndrome. We conducted this study to evaluate the effect of cyclosporine and its combination with …
IG Okpechi, OI Ameh - NEPHROLOGY, 2018 - pdfs.semanticscholar.org
BACKGROUND Glomerular diseases are a significant cause of chronic kidney disease (CKD) in many low-tomiddle-income countries (LMIC), and CKD has been associated with a …
D Schrey, TJ Walsh, AH Groll - Side Effects of Drugs Annual, 2010 - Elsevier
Publisher Summary This chapter describes the adverse effects of antifungal drugs, such as terbinafine (allylamines), amphotericin, azoles, and echinocandins. Terbinafine can cause a …