Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …

AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …

[HTML][HTML] Pathogenesis and therapy of primary cutaneous T-cell lymphoma: Collegium Internationale Allergologicum (CIA) update 2020

M Bobrowicz, C Fassnacht, D Ignatova… - International archives of …, 2020 - karger.com
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology
with a complex immunological background. As CTCL arises from T cells that have a vital role …

MicroRNAs in the pathogenesis, diagnosis, prognosis and targeted treatment of cutaneous T-cell lymphomas

M Gluud, A Willerslev-Olsen, LMR Gjerdrum… - Cancers, 2020 - mdpi.com
Cutaneous T-cell lymphoma (CTCL) represents a heterogeneous group of potentially
devastating primary skin malignancies. Despite decades of intense research efforts, the …

Environmental and other extrinsic risk factors contributing to the pathogenesis of cutaneous T cell lymphoma (CTCL)

FM Ghazawi, N Alghazawi, M Le… - Frontiers in …, 2019 - frontiersin.org
The applications of disease cluster investigations in medicine have developed rather rapidly
in recent decades. Analyzing the epidemiology of non-random aggregation of patients with a …

Protocol for adhesion and immunostaining of lymphocytes and other non-adherent cells in culture

M Tsang, J Gantchev, FM Ghazawi, IV Litvinov - Biotechniques, 2017 - Taylor & Francis
Immunostaining of non-adherent cells is commonly performed after adhesion of cells onto
microscope slides either using cytocentrifugation or with the help of charged coating …

New JAK3-INSL3 Fusion Transcript—An Oncogenic Event in Cutaneous T-Cell Lymphoma

LR Velatooru, CH Hu, P Bijani, X Wang, P Bojaxhi… - Cells, 2023 - mdpi.com
Constitutively activated tyrosine kinase JAK3 is implicated in the pathogenesis of cutaneous
T-cell lymphomas (CTCL). The mechanisms of constitutive JAK3 activation are unknown …

[HTML][HTML] BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition

SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza… - Oncotarget, 2018 - ncbi.nlm.nih.gov
While several systemic therapies are approved for cutaneous T cell lymphoma (CTCL), a
non-Hodgkin lymphoma of skin-homing T cells that may involve lymph nodes and peripheral …

Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity

S Poglio, M Prochazkova-Carlotti, F Cherrier, A Gros… - Leukemia, 2021 - nature.com
Sézary Syndrome (SS) is a rare aggressive epidermotropic cutaneous T-cell lymphoma
(CTCL) defined by erythroderma, pruritis, and a circulating atypical CD4+ T-cell clonal …

Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

E Blümel, A Willerslev-Olsen, M Gluud… - …, 2019 - Taylor & Francis
Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma
(CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well …

Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

E Blümel, S Munir Ahmad, C Nastasi… - …, 2020 - Taylor & Francis
Staphylococcus aureus and its toxins have been linked to disease progression and mortality
in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role …