Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by
mutations in the CF Transmembrane-Conductance Regulator (CFTR) gene. Unrelenting …

Recent developments in the prediction of local aerosol deposition in human lungs are driven
by the fast development of computational simulations. Although such simulations provide …

During breathing, lung inflation is a dynamic process involving a balance of mechanical
factors, including trans-pulmonary pressure gradients, tissue compliance and airway …

Computed tomography (CT) and spirometry are the mainstays of clinical pulmonary
assessment. Spirometry is effort dependent and only provides a single global measure that …

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function
and may be characteristic of early pulmonary disease. While standard indices like …

Dry powder inhalers (DPIs) delivering antibiotics for the suppressive treatment of
Pseudomonas aeruginosa in cystic fibrosis patients were developed recently and are now …

Small-animal physiology studies are typically complicated, but the level of complexity is
greatly increased when performing live-animal X-ray imaging studies at synchrotron and …

A basic prerequisite for in vivo X-ray imaging of the lung is the exact determination of
radiation dose. Achieving resolutions of the order of micrometres may become particularly …

Most measures of lung health independently characterise either global lung function or
regional lung structure. The ability to measure airflow and lung function regionally would …

Rationale X-ray velocimetry (XV) has been utilized in preclinical models to assess lung
motion and regional ventilation, though no studies have compared XV-derived physiologic …