Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …

Neural circuits can be reconstructed from brain images acquired by serial section electron
microscopy. Image analysis has been performed by manual labor for half a century, and …

Cellular-resolution connectomics is an ambitious research direction with the goal of
generating comprehensive brain connectivity maps using high-throughput, nano-scale …

Detailed knowledge of biological structure has been key in understanding biology at several
levels of organisation, from organs to cells and proteins. Volume electron microscopy …

Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes …

MRI provides a unique non-invasive window into the brain, yet is limited to millimeter
resolution, orders of magnitude coarser than cell dimensions. Here, we show that diffusion …

Large-scale connectomic reconstruction of neural circuitry at single-synapse resolution is an
attractive target for improving understanding of the nervous system in health and disease …

One way to assess a neuron's function is to describe all its inputs and outputs. With this goal
in mind, we used serial section electron microscopy to map 899 synaptic inputs and 623 …