Neuronal specification in space and time

I Holguera, C Desplan - Science, 2018 - science.org
To understand how neurons assemble to form functional circuits, it is necessary to obtain a
detailed knowledge of their diversity and to define the developmental specification programs …

Origin, development, and synaptogenesis of cortical interneurons

A Llorca, R Deogracias - Frontiers in Neuroscience, 2022 - frontiersin.org
The mammalian cerebral cortex represents one of the most recent and astonishing
inventions of nature, responsible of a large diversity of functions that range from sensory …

[HTML][HTML] Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice

Y Printz, P Patil, M Mahn, A Benjamin, A Litvin… - Nature …, 2023 - nature.com
The medial prefrontal cortex (mPFC) mediates a variety of complex cognitive functions via its
vast and diverse connections with cortical and subcortical structures. Understanding the …

GABAergic restriction of network dynamics regulates interneuron survival in the developing cortex

ZRS Duan, A Che, P Chu, L Modol, Y Bollmann… - Neuron, 2020 - cell.com
During neonatal development, sensory cortices generate spontaneous activity patterns
shaped by both sensory experience and intrinsic influences. How these patterns contribute …

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Z Zhao, D Zhang, F Yang, M Xu, S Zhao, T Pan, C Liu… - Cell research, 2022 - nature.com
The differences in size and function between primate and rodent brains, and the association
of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight …

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

D Orduz, N Benamer, D Ortolani, E Coppola… - Nature …, 2019 - nature.com
The first wave of oligodendrocyte precursor cells (firstOPCs) and most GABAergic
interneurons share common embryonic origins. Cortical firstOPCs are thought to be …

Generation of diverse cortical inhibitory interneurons

KT Sultan, SH Shi - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
First described by Ramon y Cajal as 'short‐axon'cells over a century ago, inhibitory
interneurons in the cerebral cortex make up~ 20–30% of the neuronal milieu. A key feature …

Development, diversity, and death of MGE-derived cortical interneurons

RH Williams, T Riedemann - International Journal of Molecular Sciences, 2021 - mdpi.com
In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key
neurophysiological question concerns how each class of INs contributes to cortical circuit …

Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits

S Bello-Rojas, MW Bagnall - Elife, 2022 - elifesciences.org
Shared lineage has diverse effects on patterns of neuronal connectivity. In mammalian
cortex, excitatory sister neurons assemble into shared microcircuits. In Drosophila, in …

The circuit motif as a conceptual tool for multilevel neuroscience

O Braganza, H Beck - Trends in neurosciences, 2018 - cell.com
Modern neuroscientific techniques that specifically manipulate and measure neuronal
activity in behaving animals now allow bridging of the gap from the cellular to the behavioral …