Originally regarded as just membrane constituents and energy storing molecules, lipids are
now recognised as potent signalling molecules that regulate a multitude of cellular …

Abstract Leukotriene B4 (LTB4) is a potent chemoattractant that is primarily involved in
inflammation, immune responses and host defence against infection. LTB4 activates …

Lipoxins (LXs) or the lipoxygenase interaction products are generated from arachidonic acid
via sequential actions of lipoxygenases and subsequent reactions to give specific …

Before we discuss lipids and their role in homeostasis and host defense, we will recount the
essence of the inflammatory response. Inflammation is a reaction of the microcirculation; it's …

Lipoxin A4 (LXA4) triggers selective responses with human neutrophils that are pertussis
toxin sensitive and binds to high affinity receptors (Kd= 0.5+/-0.3 nM) that are modulated by …

Lipoxins are bioactive eicosanoids that are immunomodulators. In human myeloid cells,
lipoxin (LX) A4 actions are mediated by interaction with a G protein–coupled receptor. To …

We have previously reported (Badolato, R., JM Wang, WJ Murphy, AR Lloyd, DF Michiel, LL
Bausserman, DJ Kelvin, and JJ Oppenheim. 1994. J. Exp. Med. 180: 203; Xu, L., R …

Resolution of inflammation, an actively coordinated program, is essential to maintain host
health. It involves effective removal of inflammatory stimuli and the spatio-temporal control of …

Lipoxins (LX) are bioactive eicosanoids that activate human monocytes and inhibit
neutrophils. LXA 4 is rapidly converted by monocytes to inactive products, and to resist …

The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by
inflammation-associated cytokines and a high concentration of circulating SAA may …