Insights into genetics and pathophysiology of arrhythmogenic cardiomyopathy

B Gerull, A Brodehl - Current Heart Failure Reports, 2021 - Springer
Abstract Purpose of Review Arrhythmogenic cardiomyopathy (ACM) is a genetic disease
characterized by life-threatening ventricular arrhythmias and sudden cardiac death (SCD) in …

[HTML][HTML] Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging

L Pio-Lopez, M Levin - Drug Discovery Today, 2023 - Elsevier
Highlights•Growth, form and function of complex organs rely on dynamic morphogenesis.•
Morphoceuticals manipulate anatomical decision making by cellular collectives.• …

Bioelectricity in developmental patterning and size control: evidence and genetically encoded tools in the zebrafish model

MR Silic, GJ Zhang - Cells, 2023 - mdpi.com
Developmental patterning is essential for regulating cellular events such as axial patterning,
segmentation, tissue formation, and organ size determination during embryogenesis …

Small-molecule inhibitors of tankyrases as prospective therapeutics for cancer

M Yu, Y Yang, M Sykes, S Wang - Journal of Medicinal Chemistry, 2022 - ACS Publications
Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchymal cells

ML Follmer, TJ Isner, YH Ozekin, CH Levitt… - Nature …, 2024 - nature.com
Abstract Bone Morphogenetic Protein (BMP) signaling is essential for craniofacial
development, though little is known about the mechanisms that govern BMP secretion. We …

Osteogenesis of bone marrow mesenchymal stem cell in hyperglycemia

M Luo, Z Zhao, J Yi - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes mellitus (DM) has been shown to be a clinical risk factor for bone diseases
including osteoporosis and fragility. Bone metabolism is a complicated process that requires …

Aging as a morphostasis defect: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - 2024 - osf.io
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. We argue here that the …

Assessment of heterozygosity and genome-wide analysis of heterozygosity regions in two Duroc pig populations

D Ruan, J Yang, Z Zhuang, R Ding, J Huang… - Frontiers in …, 2022 - frontiersin.org
Heterozygosity can effectively reflect the diverse models of population structure and
demographic history. However, the genomic distribution of heterozygotes and the correlation …

Aging as a loss of morphostatic information: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - Ageing Research Reviews, 2024 - Elsevier
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …

The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy

N Yadav, S Anand, J Banerjee, M Tripathi… - …, 2024 - Elsevier
Epilepsy is a neurological disorder characterised by unprovoked, repetitive seizures caused
by abnormal neuronal firing. The Wnt/β–Catenin signalling pathway is involved in seizure …