The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Discoidin domain receptors, DDR1 and DDR2, lie at the intersection of two large receptor
families, namely the extracellular matrix and tyrosine kinase receptors. As such, DDRs are …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown
via gene knockout and use of antisense oligonucleotides; however, these techniques act via …

Abstract Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

Background Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is
activated by collagens that is involved in the pathogenesis of fibrotic disorders. Interestingly …

Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …

The role of peroxisome proliferator-activated receptor (PPAR) β/δ in hepatic fibrosis remains
a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the …