It is of vital importance to reversibly mask and selectively activate bioactive agents for
advanced therapeutic and diagnostic purposes, aiming to efficiently suppress background …

Self-immolative drug delivery system is one of the delivery systems, which have drawn
attention, in recent research, highlighting the improvement they generate in drug selectivity …

Combination of anticancer drugs with therapeutic microRNA (miRNA) has emerged as a
promising anticancer strategy. However, the promise is hampered by a lack of desirable …

The research and development of non-viral gene therapy has been extensive over the past
decade and has received a big push thanks to the recent successful approval of non-viral …

Combination therapy targeting multiple therapeutic targets is a favorable strategy to achieve
better therapeutic outcomes in cancer and inflammatory diseases. Codelivery is a subfield of …

Single drug therapy that leads to the multidrug resistance of cancer cells and severe side-
effect is a thing of the past. Combination therapies that affect multiple signaling pathways …

Highlights•Clinical evaluation of nanocarriers for macromolecules is discussed.•
Nanocarriers for immunotherapy and gene delivery have advanced to the clinic.•Challenges …

Stimuli-responsive self-immolative polymers (SIPs) represent a unique class of polymers
that can undergo controlled, sequential head-to-tail depolymerization upon specific stimuli …

Polyamines are small polycationic alkylamines involved in many fundamental cellular
processes, including cell proliferation, survival, and protection from oxidative stress …

The major challenges of non-viral carriers are low transfection efficiency and high toxicity. To
overcome this bottleneck, it is very important to investigate the structure-property-function …