Generative molecular design for drug discovery and development has seen a recent
resurgence promising to improve the efficiency of the design-make-test-analyse cycle; by …

Retroviruses are distinguished from other viruses by two characteristic steps in the viral
replication cycle. The first is reverse transcription, which results in the production of a double …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Lens epithelium–derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase
that promotes viral integration by tethering the preintegration complex to the chromatin. By …

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75,
which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant …

HIV-1 integrase is a multidomain enzyme which is required for the integration of viral DNA
into the host genome. It is one of three enzymes of HIV, the others being the Reverse …

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular
cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome …

Background To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA
genomes into host cell chromosomes. Lentiviral integration is favored in active transcription …

Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …

tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase
(IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to …