Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is
present in most body tissues, usually in combination with other collagens and other …

While a fraction of cancer patients treated with anti–PD-1 show durable therapeutic
responses, most remain unresponsive, highlighting the need to better understand and …

Increased collagen deposition by breast cancer (BC)-associated mesenchymal
stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are …

Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective
tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this …

Systemic sclerosis (SSc) is an idiopathic autoimmune disease with a heterogeneous clinical
phenotype ranging from limited cutaneous involvement to rapidly progressive diffuse SSc …

Discoidin domain receptors (DDRs), including DDR1 and DDR2, are a unique class of
receptor tyrosine kinases (RTKs) activated by collagens at the cell-matrix boundary …

The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor
epithelial cells, a process associated with the emergence of stemness, invasion and cancer …

The interleukin (IL)-20 subfamily of cytokines consists of IL-19, IL-20, IL-22, IL-24, and IL-26,
and the expression of IL-20, IL-22, and IL-24 is reported to be higher in the colon of patients …

Objective This study was undertaken to uncover the pathophysiologic role of discoidin
domain receptor 2 (DDR‐2), a putative fibrillar collagen receptor, in inflammation promotion …