Individual and population differences in polymorphic cytochrome P 450 enzyme function
have been known for decades. The biological significance of these differences has now …

The cytochrome P450 (CYP) gene superfamily comprises a large group of hemoproteins
with diverse functions in steroid, lipid, and xenobiotic metabolism. The human genome is …

Copy number variations (CNVs) in the human genome are conventionally detected using
high-throughput scanning technologies, such as comparative genomic hybridization and …

Background Cigarette smoking is consistently more common among schizophrenia patients
than the general population worldwide; however, the findings of studies in Japan are …

Objectives: Our group has previously show that interindividual variability in CYP2D6
hydroxylation capacity was related to personality differences in cognitive social anxiety …

The CYP2D6 gene is highly polymorphic, causing absent (poor metabolizers), decreased,
normal or increased enzyme activity (extensive and ultrarapid metabolizers). The genetic …

Aims: A lower serotonin/higher dopamine tone in CYP2D6 poor metabolizers (PMs) versus
extensive metabolizers (EMs) has been postulated, which is consistent with our prior …

Integrating gene expression profiles with certain proteins can improve our understanding of
the fundamental mechanisms in protein–ligand binding. This paper spotlights the integration …

Anorexia nervosa (AN), bulimia nervosa (BN) and binge-eating disorder (BED) are the three
main eating disorders. Antidepressants, antipsychotics, anticonvulsants, prokinetic agents …

In order to ascertain data availability and feasibility for conducting cost–effectiveness studies
in pharmacogenetics, and as part of a European Commission Joint Research Center …