Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Ferroptosis is a newly discovered form of regulated cell death that is the nexus between
metabolism, redox biology, and human health. Emerging evidence shows the potential of …

Lipid peroxides accumulation induced ferroptosis is an effective cell death pathway for
cancer therapy. However, the hypoxic condition of tumor microenvironment significantly …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the
inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro …

Hypoxia has been firmly correlated to the drug resistance of solid tumors. Alleviation of
hypoxia by tumor reoxygenation is expected to sensitize the chemotherapy toward solid …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …