Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …

Abstract About 10% to 15% of the nuclear genes of eukaryotic organisms encode
mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by …

Most of the mitochondrial proteome originates from nuclear genes and is transported into the
mitochondria after synthesis in the cytosol. Complex machineries which maintain the …

The eukaryotic heat shock response is an ancient and highly conserved transcriptional
program that results in the immediate synthesis of a battery of cytoprotective genes in the …

Efficient movement of proteins across membranes is required for cell health. The
translocation process is particularly challenging when the channel in the membrane through …

Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates
upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial …

Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …

Mitochondria import nuclear‐encoded precursor proteins to four different subcompartments.
Specific import machineries have been identified that direct the precursor proteins to the …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-
encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to …