Synthetic heterocyclic derivatives as kinase inhibitors tested for the treatment of neuroblastoma
F Musumeci, A Cianciusi, I D'Agostino, G Grossi… - Molecules, 2021 - mdpi.com
In the last few years, small molecules endowed with different heterocyclic scaffolds have
been developed as kinase inhibitors. Some of them are being tested at preclinical or clinical …
been developed as kinase inhibitors. Some of them are being tested at preclinical or clinical …
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research
R Sharma, J Yadav, SA Bhat, A Musayev… - Molecular …, 2025 - Springer
This review explores the current understanding and recent advancements in neuroblastoma,
one of the most common extracranial solid pediatric cancers, accounting for~ 15% of …
one of the most common extracranial solid pediatric cancers, accounting for~ 15% of …
Targeting fibroblast growth factor receptor (FGFR) and phosphoinositide 3-kinase (PI3K) signaling pathways in medulloblastoma cell lines
S Holzhauser, M Lukoseviciute, T Andonova… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Medulloblastoma (MB) accounts for~ 20% of pediatric malignant central
nervous system tumors. Treatment strategies, including surgery, radiation therapy and/or …
nervous system tumors. Treatment strategies, including surgery, radiation therapy and/or …
Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin
P Bhoopathi, AK Pradhan, MD Bacolod, L Emdad… - Oncogene, 2019 - nature.com
Despite multi-modality treatments, prognosis for advanced stage neuroblastoma (NB)
remains challenging with residual long-term disabilities in survivors. Advanced stage NB is …
remains challenging with residual long-term disabilities in survivors. Advanced stage NB is …
[HTML][HTML] Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy
NK Chaturvedi, MJ Kling, DW Coulter, TR McGuire… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Aberrant activation and interactions of hedgehog (HH) and PI3K/AKT/mTOR signaling
pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined …
pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined …
Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway
Background Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is
used in the treatment of many types of cancers including leukemia, but it has significant side …
used in the treatment of many types of cancers including leukemia, but it has significant side …
CARM1-induced lncRNA NEAT1 synchronously activates MYCN and GalNAcT-I to accelerate the progression of neuroblastoma
Z Hu, W Xu, H Wang, M Li, J Wang, C Sun, X Yang - Gene, 2025 - Elsevier
Abstract Purpose Long non-coding RNAs (lncRNAs) play important roles in progression of
neuroblastoma (NB). LncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been …
neuroblastoma (NB). LncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been …
MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of …
ZX Yue, C Huang, C Gao, TY Xing, SG Liu, XJ Li… - Cancer cell …, 2017 - Springer
Background MYCN gene amplification is related to risk stratification. Therefore it is important
to identify accurately the level of the MYCN gene as early as possible in neuroblastoma …
to identify accurately the level of the MYCN gene as early as possible in neuroblastoma …
Targeting PI3K, FGFR, CDK4/6 signaling pathways together with cytostatics and radiotherapy in two medulloblastoma cell lines
M Lukoseviciute, H Maier… - Frontiers in …, 2021 - frontiersin.org
Objectives Medulloblastoma (MB) is treated with surgery and chemotherapy, with or without
irradiation, but unfortunately> 20% of the patients are not cured, and treatment comes with …
irradiation, but unfortunately> 20% of the patients are not cured, and treatment comes with …
LncRNA DLX6-AS1 promotes the progression of neuroblastoma by activating STAT2 via targeting miR-506-3p
Y Hu, H Sun, J Hu, X Zhang - Cancer Management and Research, 2020 - Taylor & Francis
Background Neuroblastoma (NB) is a common malignant tumor of the sympathetic nervous
system, mainly disturbing children. Long non-coding RNAs (lncRNAs) serving as promising …
system, mainly disturbing children. Long non-coding RNAs (lncRNAs) serving as promising …