cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in
response to genomic instability and DNA damage, thereby providing host defense against …
response to genomic instability and DNA damage, thereby providing host defense against …
Structure-based mechanisms of 2′ 3′-cGAMP intercellular transport in the cGAS–STING immune pathway
Upon activation by double-stranded DNA (dsDNA), the cytosolic dsDNA sensor cyclic GMP-
AMP synthase (cGAS) synthesizes the diffusible cyclic dinucleotide 2′ 3′-cGAMP (cyclic …
AMP synthase (cGAS) synthesizes the diffusible cyclic dinucleotide 2′ 3′-cGAMP (cyclic …
Structural basis of purine nucleotide inhibition of human uncoupling protein 1
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its
specialized ability to burn calories as heat for thermoregulation. When activated by fatty …
specialized ability to burn calories as heat for thermoregulation. When activated by fatty …
Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …
Molecular basis for substrate recognition and transport of human GABA transporter GAT1
A Zhu, J Huang, F Kong, J Tan, J Lei, Y Yuan… - Nature Structural & …, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
JL Parker, T Kato, G Kuteyi, O Sitsel… - Nature Structural & …, 2023 - nature.com
In mammals, the kidney plays an essential role in maintaining blood homeostasis through
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …
Recognition of cyclic dinucleotides and folates by human SLC19A1
Q Zhang, X Zhang, Y Zhu, P Sun, L Zhang, J Ma… - Nature, 2022 - nature.com
Cyclic dinucleotides (CDNs) are ubiquitous signalling molecules in all domains of life,.
Mammalian cells produce one CDN, 2′ 3′-cGAMP, through cyclic GMP–AMP synthase …
Mammalian cells produce one CDN, 2′ 3′-cGAMP, through cyclic GMP–AMP synthase …
Methotrexate recognition by the human reduced folate carrier SLC19A1
Folates are essential nutrients with important roles as cofactors in one-carbon transfer
reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of …
reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of …
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
New and emerging research on solute carrier and ATP binding cassette transporters in drug discovery and development: outlook from the international transporter …
Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …